Adjust it to where you need it. Too far in is not a problem other than at full A/F screw closure the bike should stall and even just a tiny bit out, it might stall. Of more concern is going too far out. I have never heard of needing to go more than 3 full turns out. Did you make sure to remove the old o-ring, washer, and spring when you installed the new Glen's A/F screw and did you put the new o-ring, washer, and spring onto the end of Glen's A/F screw in the proper order (o-ring then washer, then spring going from point of screw toward knob end.